adj. Not of natural origin; prepared or made by humans; artificial; of substances, made by chemical reaction rather than extracted from a natural source; as, man-made fibers; man-made gems. Opposed to natural. Syn. -- semisynthetic, synthetic. [ WordNet 1.5 ]
[その(P);えん(P), sono (P); en (P)] (n, n-suf) (1) (えん usually when a suffix) (See りんご園) garden (esp. man-made); orchard; park; plantation; (2) (See 学びの園) place; location; (P)#1581