(n) the act of disturbing the mind or body, Syn. derangement, overthrow, Example:his carelessness could have caused an ecological upset; she was unprepared for this sudden overthrow of their normal way of living
The Collaborative International Dictionary of English (GCIDE) v.0.53 Collaborative International Dictionary (GCIDE)
n. [ Cf. F. dérangement. ] The act of deranging or putting out of order, or the state of being deranged; disarrangement; disorder; confusion; especially, mental disorder; insanity.